In 1926, this laboratory laid the foundation for the establishment of the Tbilisi Institute of Public Health, which in 1966 was later transformed into the Scientific-Research Institute of Hygiene of the Ministry of Health of the Soviet Socialist Republic of Georgia in the USSR. After the restoration of Georgia's independence in 1991, GNHI underwent many developments and changes.
In 2012, GNHI became a private research institute, which significantly expanded the range of its activities in the fields of hygiene, medical ecology, food safety and environmental protection. In 2013-2014, GNHI was ranked 3rd among the top seven companies in Georgia, and 2nd among the top three companies operating specifically in Tbilisi, according to the Association for National Business Ratings (NBR), the official comprehensive ranking of national business ratings. Statistical Service of Georgia (Sakstat).
In 2014-2016, GNHI received a gold rating from NBR in the category of "General and Financial Management", both throughout Georgia and locally in Tbilisi, and was named a leading company among the top 10 companies in the country.